Duncan Jodrell Selected Research

N-(2-hydroxypropyl)methacrylamide co-polymer-doxorubicin conjugate

6/2009

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer.

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Duncan Jodrell Research Topics

Disease

8	Neoplasms (Cancer) 12/2019 - 02/2004
5	Colorectal Neoplasms (Colorectal Cancer) 06/2009 - 06/2005
4	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018 - 08/2012
2	Colonic Neoplasms (Colon Cancer) 07/2009 - 06/2005
2	Breast Neoplasms (Breast Cancer) 06/2009 - 04/2009
2	Lymphoma (Lymphomas) 04/2009 - 05/2008
1	Adenocarcinoma 01/2018
1	Cachexia 10/2012
1	Emphysema 10/2012
1	Disease Progression 10/2012
1	Chronic Obstructive Pulmonary Disease (COPD) 10/2012
1	Breast Cancer 3 06/2009
1	Melanoma (Melanoma, Malignant) 04/2009
1	Circulating Neoplastic Cells 04/2009
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2009
1	Thrombocytopenia (Thrombopenia) 04/2009
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2009
1	Hypophosphatemia 04/2009
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 04/2009
1	Ascites 03/2009
1	Pleural Effusion (Pleural Effusions) 03/2009
1	Edema (Dropsy) 03/2009
1	Hypoalbuminemia 03/2009
1	Chest Pain (Chest Pains) 01/2009
1	Myalgia 05/2008
1	Neutropenia 02/2004

Drug/Important Bio-Agent (IBA)

3	Gemcitabine FDA Link 01/2018 - 08/2012
3	Capecitabine (Xeloda)FDA Link 01/2009 - 06/2005
3	Fluorouracil (Carac)FDA LinkGeneric 07/2005 - 02/2004
2	3- (4- ((4- chlorophenyl)sulfonyl)- 4- (2,5- difluorophenyl)cyclohexyl)propanoic acidIBA 01/2018 - 08/2012
2	EnzymesIBA 04/2009 - 05/2008
2	Leucovorin (Folinic Acid)FDA Link 07/2005 - 06/2005
1	IsotopesIBA 12/2019
1	CreatinineIBA 12/2019
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018
1	Cytokine Receptor gp130IBA 01/2016
1	PeriostinIBA 01/2016
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2016
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016
1	Janus Kinase 2IBA 01/2016
1	Proteins (Proteins, Gene)FDA Link 01/2016
1	CollagenIBA 01/2016
1	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 01/2016
1	AsparagineIBA 10/2012
1	N 30IBA 10/2012
1	Amino Acids FDA Link 10/2012
1	Arginine (L-Arginine)FDA Link 10/2012
1	1-methylhistidineIBA 10/2012
1	Aspartic Acid (Aspartate)FDA Link 10/2012
1	gamma-Aminobutyric Acid (GABA)IBA 10/2012
1	Glutamine (L-Glutamine)FDA Link 10/2012
1	GoldIBA 10/2012
1	MethylhistidinesIBA 10/2012
1	Sarcosine (Methylglycine)IBA 10/2012
1	Serine (L-Serine)FDA Link 10/2012
1	Tryptophan (L-Tryptophan)FDA Link 10/2012
1	Biomarkers (Surrogate Marker)IBA 10/2012
1	Taxoids (Taxanes)IBA 07/2009
1	PolymersIBA 06/2009
1	N-(2-hydroxypropyl)methacrylamide co-polymer-doxorubicin conjugateIBA 06/2009
1	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2009
1	AnthracyclinesIBA 06/2009
1	Messenger RNA (mRNA)IBA 04/2009
1	X-Linked Inhibitor of Apoptosis ProteinIBA 04/2009
1	Docetaxel (Taxotere)FDA Link 04/2009
1	AEG 35156IBA 04/2009
1	DNA (Deoxyribonucleic Acid)IBA 03/2009
1	Pharmaceutical PreparationsIBA 03/2009
1	1,1'- ((propane- 1,3- diyl)dioxy)bis(7- methoxy- 2- methylidene- 1,2,3,10,11,11a- hexahydro- 5H- pyrrolo(2,1- c)(1,4)benzodiazepin- 5,11- dione)IBA 03/2009
1	plitidepsin (aplidine)IBA 05/2008
1	Creatine Kinase (Creatine Phosphokinase)IBA 05/2008
1	Warfarin (Coumadin)FDA LinkGeneric 07/2005
1	Platinum Compounds (Compounds, Platinum)IBA 02/2004
1	BBR 3464 (BBR3464)IBA 02/2004

Therapy/Procedure

4	Therapeutics 10/2012 - 02/2004
2	Intravenous Infusions 04/2009 - 05/2008
2	Drug Therapy (Chemotherapy) 04/2009 - 01/2009
1	Aftercare (After-Treatment) 07/2007
1	Adjuvant Chemotherapy 07/2005